About Us

Dr. Fernando Muzzio // President, Integra CMS

Dr. Fernando Muzzio is the president of Integra Continuous Manufacturing Systems, where he drives company strategy, applying extensive experience in pharmaceutical product and process design, with emphasis on continuous manufacturing. He is also the Director of the National Science Foundation (NSF) Engineering Research Center on Structured Organic Particulate Systems (C-SOPS) and a Distinguished Professor at Rutgers University in the department of Chemical and Biochemical Engineering, and a member of the graduate program in Pharmaceutics at the Rutgers School of Pharmacy.

Dr. Muzzio is a consulting member of the FDA Committee on Pharmaceutical Sciences and clinical pharmacology and a member of the USP expert committee on Continuous Manufacturing. As a core advocate, researcher, and developer of continuous manufacturing for the industry, Dr. Muzzio has built an extensive network, and has made a profound impact on the industry. His work as the Rutgers Program Director of the Janssen/Rutgers partnership in advanced Pharmaceutical Manufacturing to redevelop the manufacturing process for Prezista resulted in implementation of the Inspire Continuous Manufacturing program at Rutgers and Janssen Pharmaceutica in Gurabo, Puerto Rico.

Dr. Muzzio holds a PhD from the University of Massachusetts at Amherst and a BS degree from the University of Mar del Plata in Argentina, both in Chemical Engineering. He has authored more than 270 peer-reviewed scientific articles and numerous book chapters and patents. In 2016, the NJ Inventors Hall of Fame awarded Dr. Muzzio the Inventor of the Year Award for his contributions to continuous pharmaceutical manufacturing.

Daisy Rivera Muzzio // COO, Integra CMS

Daisy Rivera Muzzio is the business owner and president of Acumen BioPharma, and serves as Chief Operating Officer (COO) at Integra CMS. In her Integra CMS role, she is responsible for all business operations and management of contractual alliances, drawing on her deep expertise in the evaluation and risk assessment of licensing generic formulations, and conducting cross-functional analyses for licensing and acquisition of several major platform technologies.

Rivera-Muzzio holds a Master of Science in Industrial Pharmacy and Bachelor of Science in Pharmacy from the University of Puerto Rico. She earned her MBA from Massachusetts Institute of Technology (MIT) in Cambridge, MA. She has served as the VP of Programs for the MIT Alumni NNJ Chapter and as co-Chair of the NJ Chapter of Licensing Executive Society (LES), and volunteers to support STEM education for underprivileged children. She is also an active member of the MIT Educational Council of Princeton, NJ and of the Healthcare Businesswomen Association (HBA).

Eric J. Sánchez // Consultant, Integra CMS

Eric J. Sánchez is a Consultant at Integra CMS with a special focus on implementation of continuous manufacturing methods.

Sánchez brings an unparalleled reservoir of fundamental knowledge and practical experience in continuous manufacturing. He recently retired from Janssen Pharmaceuticals (JnJ) after a very successful 31-year career. His final role at JnJ as Director of Advanced Technologies included leading the development and implementation of the INSPIRE continuous manufacturing line at Gurabo, Puerto Rico. This project, which was the hallmark of the 15-year collaboration on advanced manufacturing between JnJ and C-SOPS, enabled the conversion of Prezista from batch to continuous manufacturing, which was approved by FDA in 2016 and has been approved in 11 additional countries since then.

Sánchez also played a key role in the acquisition, implementation, and operation of continuous manufacturing lines in Latina, Italy, and in Beerse, Belgium. Prior to that, Eric was a scientific fellow and the director of Global Technical Operations at Janssen Pharmaceuticals. In this role, Eric was responsible for product transfer, process validation, process scale-up, and technical operations support for a wide range of manufacturing processes at multiple sites.

This direct experience, encompassing research, development, technology transfer, program management, technical operations, and multiple collaborations with academia and with other companies, combined with an enormous enthusiasm for science-based development of manufacturing processes and strong capabilities to organize and lead multifunctional teams, makes him an indispensable member of our team.

As part of the Integra team, Eric will support customers in selecting the right products and the correct strategy to implement advanced manufacturing technologies. He will provide effective interactions with equipment vendors and with academic partners who can assist in developing formulations, manufacturing processes, and quality systems.

Integra CMS main mission is to enable customers to select, develop, and implement custom-tailored advanced manufacturing solutions that are both cost effective and highly capable. Working within the powerful systematic methods developed by Integra CMS, Eric will use his experience and knowledge to ensure the success of our customers.

Dr. Marianthi G. Ierapetritou // Senior Consultant, Integra CMS

Dr. Marianthi Ierapetritou is a Senior Consultant at Integra CMS with more than 15 years of experience in pharmaceutical manufacturing. She is also a Distinguished Professor and former Chair of the Department of Chemical & Biochemical Engineering at Rutgers University, and a Special Government Employee (SGE) Consultant to the FDA under the Advisory Committee for Pharmaceutical Science and Clinical Pharmacology (ACPS-CP).

She led the team at Rutgers University that developed the flowsheet modeling framework that is quickly becoming the worldwide standard at companies, major universities, and regulatory agencies for analysis, design, and optimization of continuous manufacturing systems.

Dr. Ierapetritou gained her PhD from the Chemical Engineering Department at Imperial College, London, UK with research interests in computer-aided process and product design; production planning, scheduling and supply chain management; modeling and optimization of pharmaceutical processes; and metabolic engineering and optimization. She has authored three books and more than 200 peer-reviewed scientific articles and book chapters.

Stephen V. Hammond // Senior Consultant, Integra CMS

Steve Hammond is a Senior Consultant at Integra CMS with more than 39 years of analytical industry experience at Pfizer Pharmaceuticals. His expertise lies in the development and deployment of Process Analytical Sciences, including forensic analysis support to the plant network.

As a core driver of the development and deployment of Process Analytical Technologies (PAT) during the development of Pfizer’s Continuous Manufacturing platform, he gained insight into the successful integration of real time measurement systems and associated control systems at critical points of the manufacturing process flow (to ensure process robustness and performance, leading to product quality and compliance).

Hammond holds an MS in Analytical Chemistry from the University of Kent, UK. He is a Graduate of the Royal Institute of Chemistry, London, UK and obtained the status of Chartered Chemist in the UK by examination. He is also a member of the Royal Society of Chemistry.

San Kiang // Senior Consultant, Integra CMS

San Kiang is a Senior Consultant in continuous processing for Active Pharmaceutical Ingredients (API) and Drug Product (DP) process development with focus on particle engineering, pharmaceutical composite materials (PCM), co-processing and pharmaceutical process scale-up. He is also a contributor to Rutgers University research to enable continuous manufacturing of API and Continuous Direct Compression of finished product with emphasis on process transfer to pilot and manufacturing scales.

Kiang has developed PCM in which API and excipients are combined under controlled conditions to produce composite materials with unique properties that can be used to address some common issues in formulation development. He has also developed particle engineering technologies to enable the use of problematic API in direct compression DP platforms.

He earned his ScD, MS and BS in Chemical Engineering from Columbia University, and has served as a Research Professor at Rutgers University, Department of Chemical and Biochemical Engineering, conducting research projects on continuous manufacturing in both API and DP and material science related to pharmaceuticals.